Fondation MEDIC

www.fondation-medic.ch

Publications
[22.10.2016]
2016
 
2016
Denkert C, Wienert S, Poterie A, Loibl S, Budczies J, Badve S, Bago-Horvath Z, Bane A, Bedri S, Brock J, Chmielik E, Christgen M, Colpaert C, Demaria S, Van den Eynden G, Floris G, Fox SB, Gao D, Ingold Heppner B, Kim SR, Kos Z, Kreipe HH, Lakhani SR, Penault-Llorca F, Pruneri G, Radosevic-Robin N, Rimm DL, Schnitt SJ, Sinn BV, Sinn P, Sirtaine N, O'Toole SA, Viale G, Van de Vijver K, de Wind R, von Minckwitz G, Klauschen F, Untch M, Fasching PA, Reimer T, Willard-Gallo K, Michiels S, Loi S, Salgado R. Standardized evaluation of tumor-infiltrating lymphocytes in breast cancer: results of the ring studies of the international immuno-oncology biomarker working group. Mod Pathol. 2016 Oct;29(10):1155-64. doi: 10.1038/modpathol.2016.109
» PubMed
2016
Legat A, Maby-El Hajjami H, Baumgaertner P, Cagnon L, Abed Maillard S, Geldhof C, Iancu EM, Lebon L, Guillaume P, Dojcinovic D, Michielin O, Romano E, Berthod G, Rimoldi D, Triebel F, Luescher I, Rufer N, Speiser DE. Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients--Report of a Phase I/IIa Clinical Trial. Clin Cancer Res. 2016;22:1330-40. doi: 10.1158/1078-0432.CCR-15-1212
» PubMed
2016
Ludigs K, Jandus C, Utzschneider DT, Staehli F, Bessoles S, Dang AT, Rota G, Castro W, Zehn D, Vivier E, Held W, Romero P, Guarda G. NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016 7:10554. doi: 10.1038/ncomms10554
» PubMed
2016
Scholz G, Jandus C, Zhang L, Grandclément C, Lopez-Mejia IC, Soneson C, Delorenzi M, Fajas L, Held W, Dormond O, Romero P. Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells. EBioMedicine. 2016;4:50-61. doi: 10.1016/j.ebiom.2016.01.019
» PubMed
2016
Verdonck M, Denayer A, Delvaux B, Garaud S, De Wind R, Desmedt C, Sotiriou C, Willard-Gallo K, Goormaghtigh E. Characterization of human breast cancer tissues by infrared imaging. Analyst. 2016 Jan 21;141(2):606-19. doi: 10.1039/c5an01512j
» PubMed
2015
 
2015
Asparuhova MB, Secondini C, Rüegg C, Chiquet-Ehrismann R. Mechanism of irradiation-induced mammary cancer metastasis: A role for SAP-dependent Mkl1 signaling. Mol Oncol. 2015 Oct;9(8):1510-27. doi: 10.1016/j.molonc.2015.04.003
» PubMed
2015
Bron S, Henry L, Faes-van’t Hull E, Turrini R, Vanhecke D, Guex N, Ifticene-Treboux A, Majo F, Nicolas M, Iancu EM, Semilietof M, Rufer N, Lehr HA, Xenarios I, Coukos G, Delaloye J.-F., Doucey M-A. TIE-2-expressing monocytes are lymphangiogenic and incorporate specifically into lymphatics of human breast cancer. Oncoimmunology. doi: 10.1080/2162402X.2015.1073882
» PubMed
2015
Chevalier MF, Bobisse S, Costa-Nunes C, Cesson V, Jichlinski P, Speiser DE, Harari A, Coukos G, Romero P, Nardelli-Haefliger D, Jandus C, Derré L. High-throughput monitoring of human tumor-specific T-cell responses with large peptide pools. Oncoimmunology. 2015;4: e1029702. doi: 10.1080/2162402X.2015.1029702
» PubMed
2015
Ciarloni L, Hosseinian S, Monnier-Benoit S, Imaizumi N, Dorta G, Ruegg C; DGNP-COL-0310 Study Group. Discovery of a 29-gene panel in peripheral blood mononuclear cells for the detection of colorectal cancer and adenomas using high throughput real-time PCR. PLoS One. 2015 Apr 13;10(4):e0123904. doi: 10.1371/journal.pone.0123904
» PubMed
2015
De Meyer T, Bady P, Trooskens G, Kurscheid S, Bloch J, Kros JM, Hainfellner JA, Stupp R, Delorenzi M, Hegi ME, Van Criekinge W. Genome-wide DNA methylation detection by MethylCap-seq and Infinium HumanMethylation450 BeadChips: an independent large-scale comparison. Sci Rep. 2015 Oct 20;5:15375.. doi: 10.1038/srep15375
» PubMed
2015
Derouazi M, Di Berardino-Besson W, Belnoue E, Hoepner S, Walther R, Benkhoucha M, Teta P, Dufour Y, Yacoub Maroun C, Salazar AM, Martinvalet D, Dietrich PY, Walker PR. Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell-Mediated Antitumor Immunity. Cancer Res. 2015 Aug 1;75(15):3020-31. doi: doi: 10.1158/0008-5472.CAN-14-3017
» PubMed
2015
Doucey MA, Xenarios I. Oncoimmunology. 2015 Jul 7;4(11):e1046674. eCollection 2015 Nov. Toward a rational design of combination therapy in cancer. Oncoimmunology. doi: e1046674.
» PubMed
2015
Dushyanthan S, Savas P, Willard-Gallo K, Denkert C, Salgado R, Loi S.. Tumor infiltrating lymphocytes (TILs) in breast cancer. Curr. Breast Cancer Rep. 7: 59. doi: 10.1007/s12609-014-0178-4
» PubMed
2015
Fagiani E, Bill R, Pisarsky L, Ivanek R, Rüegg C, Christofori G. An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models. Angiogenesis. 2015 Jul;18(3):327-45.. doi: 10.1007/s10456-015-9470-9.
» PubMed
2015
Filipovic N, Ghimire K, Saveljic I, Milosevic Z, Ruegg C. Computational modeling of shear forces and experimental validation of endothelial cell responses in an orbital well shaker system. Comput Methods Biomech Biomed Engin. 2015 Jun 22:1-10. [Epub ahead of print].
» PubMed
2015
Fischer U, Forster M, Rinaldi A, Risch T, Sungalee S, Warnatz HJ, Bornhauser B, Gombert M, Kratsch C, Stütz AM, Sultan M, Tchinda J, Worth CL, Amstislavskiy V, Badarinarayan N, Baruchel A, Bartram T, Basso G, Canpolat C, Cario G, Cavé H, Dakaj D, Delorenzi M, Dobay MP, Eckert C, Ellinghaus E, Eugster S, Frismantas V, Ginzel S, Haas OA, Heidenreich O, Hemmrich-Stanisak G, Hezaveh K, Höll JI, Hornhardt S, Husemann P, Kachroo P, Kratz CP, Kronnie GT, Marovca B, Niggli F, McHardy AC, Moorman AV, Panzer-Grümayer R, Petersen BS, Raeder B, Ralser M, Rosenstiel P, Schäfer D, Schrappe M, Schreiber S, Schütte M, Stade B, Thiele R, Weid NV, Vora A, Zaliova M, Zhang L, Zichner T, Zimmermann M, Lehrach H, Borkhardt A, Bourquin JP, Franke A, Korbel JO, Stanulla M, Yaspo ML. Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options. Nat Genet. 2015 Jul 27.. doi: doi: 10.1038/ng.3362. PMID: 26214592.
» PubMed
2015
Francesca Puppo · Marie-Agnes Doucey · Jean-Francois Delaloye · Thomas S.Y. Moh · Gregory Pandraud · Pasqualina M. Sarro · Giovanni De Micheli · Sandro Carrara. SiNW-FET in-Air Biosensors for High Sensitive and Specific Detection in Breast Tumor Extract. IEEE Sensors Journal. doi: DOI:10.1109/JSEN.2015.2433836
» PubMed
2015
Fuertes Marraco SA, Soneson C, Cagnon L, Gannon PO, Allard M, Maillard SA, Montandon N, Rufer N, Waldvogel S, Delorenzi M, Speiser DE. Long-lasting stem cell-like memory CD8+ T cells with a naïve-like profile upon yellow fever vaccination. Sci Transl Med. 2015 Apr 8;7(282):282ra48. doi: 10.1126/scitranslmed.aaa3700
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2015
Fumagalli D, Gacquer D, Rothé F, Lefort A, Libert F, Brown D, Kheddoumi N, Shlien A, Konopka T, Salgado R, Larsimont D, Polyak K, Willard-Gallo K, Desmedt C, Piccart M, Abramowicz M, Campbell PJ, Sotiriou C, Detours V. Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. Cell Rep. 2015 Oct 13;13(2):277-89. doi: 10.1016/j.celrep.2015.09.032
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2015
Gannon PO, Wieckowski S, Baumgaertner P, Hebeisen M, Allard M, Speiser DE, Rufer N. Quantitative TCR:pMHC Dissociation Rate Assessment by NTAmers Reveals Antimelanoma T Cell Repertoires Enriched for High Functional Competence. J Immunol. 2015;195:356-66. doi: 10.4049/jimmunol.1403145
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2015
Garaud S, Willard-Gallo K. IRF5: a rheostat for tumor-infiltrating lymphocyte trafficking in breast cancer?. Immunol Cell Biol. 2015 May-Jun;93(5):425-6. doi: 10.1038/icb.2015.39
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2015
Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, Marisa L, Roepman P, Nyamundanda G, Angelino P, Bot BM, Morris JS, Simon IM, Gerster S, Fessler E, De Sousa E Melo F, Missiaglia E, Ramay H, Barras D, Homicsko K, Maru D, Manyam GC, Broom B, Boige V, Perez-Villamil B, Laderas T, Salazar R, Gray JW, Hanahan D, Tabernero J, Bernards R, Friend SH, Laurent-Puig P, Medema JP, Sadanandam A, Wessels L, Delorenzi M, Kopetz S, Vermeulen L, Tejpar S. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015 Nov; 21(11):1350-6. doi: 10.1038/nm.3967
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2015
Gustavsson B, Carlsson G, Machover D, Petrelli N, Roth A, Schmoll HJ, Tveit KM, Gibson F. A review of the evolution of systemic chemotherapy in the management of colorectal cancer. Clin Colorectal Cancer. 2015 Mar;14(1):1-10. doi: 10.1016/j.clcc.2014.11.002
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2015
Hebeisen M, Allard M, Gannon PO, Schmidt J, Speiser DE, Rufer N. Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens. Front Immunol. 2015;6:582. doi: 10.3389/fimmu.2015.00582
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2015
Hebeisen M, Schmidt J, Guillaume P, Baumgaertner P, Speiser DE, Luescher I, Rufer N. Identification of Rare High-Avidity, Tumor-Reactive CD8+ T Cells by Monomeric TCR-Ligand Off-Rates Measurements on Living Cells. Cancer Res. 2015;75:1983-91. doi: 10.1158/0008-5472.CAN-14-3516
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2015
Hingorani P, Missiaglia E, Shipley J, Anderson JR, Triche TJ, Delorenzi M, Gastier-Foster J, Wing M, Hawkins DS, Skapek SX. Clinical Application of Prognostic Gene Expression Signature in Fusion Gene-Negative Rhabdomyosarcoma: A Report from the Children's Oncology Group. Clin Cancer Res. 2015 15;21(20):4733-9.. doi: 10.1158/1078-0432
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2015
Huang YT, Lan Q, Ponsonnet L, Blanquet M, Christofori G, Zaric J, Rüegg C. The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression. Oncotarget. 2015 Nov 27. doi: 10.18632/oncotarget.6411.
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2015
Ioulia Tzouvadaki · Francesca Puppo · Marie-Agnes Doucey · Giovanni De Micheli · Sandro Carrara. Computational Study on the Electrical Behavior of Silicon Nanowire Memristive Biosensors. IEEE Sensors Journal. doi: DOI:10.1109/JSEN.2015.2456336
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2015
Jensen NF, Stenvang J, Beck MK, Hanáková B, Belling KC, Do KN, Viuff B, Nygård SB, Gupta R, Rasmussen MH, Tarpgaard LS, Hansen TP, Budinská E, Pfeiffer P, Bosman F, Tejpar S, Roth A, Delorenzi M, Andersen CL, Rømer MU, Brünner N, Moreira JM. Establishment and characterization of models of chemotherapy resistance in colorectal cancer: Towards a predictive signature of chemoresistance. Mol Oncol. 2015 Feb 24. doi: doi: 10.1016/j.molonc.2015.02.008. PMID: 25759163.
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2015
Klingbiel D, Saridaki Z, Roth AD, Bosman F, Delorenzi M, Tejpar S. Prognosis of stage II and III colon carcinoma treated with adjuvant 5-FU or FOLFIRI in relation to microsatellite status, results of the PETACC-3 trial. Ann Oncol. 2015 Jan;26(1):126-32 2014 Oct 30.. doi: PMID: 25361982.
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2015
Knuchel S, Anderle P, Werfelli P, Diamantis E, Rüegg C. Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion. Oncotarget. 2015 Jun 10;6(16):14300-17..
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2015
Kurscheid S, Bady P, Sciuscio D, Samarzija I, Shay T, Vassallo I, van Criekinge W, Daniel RT, van den Bent MJ, Marosi C, Weller M, Mason WP, Domany E, Stupp R, Delorenzi M, Hegi ME. Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma. Genome Biol. 2015 Jan 27;16(1):16.. doi: PMID: 25622821.
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2015
Lotfi A, Puppo F, Doucey M-A, De Micheli G and Carrara S. Reliable Redundancy with Memristive-Biosensors to achieve Statistical Significance in Immunosensing. IWASI 2015, 6th IEEE International Workshop on Advances in Sensors and Interfaces, Gallipoli (Le), Italy. doi: Conference paper
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2015
Paquet ER, Cui J, Davidson D, Pietrosemoli N, Hassan HH, Tsofack SP, Maltais A, Hallett MT, Delorenzi M, Batist G, Aloyz R, Lebel M. A 12-gene signature to distinguish colon cancer patients with better clinical outcome following treatment with 5-fluorouracil or FOLFIRI. Ann Oncol. 2015 Jan;26(1):126-32. doi: 10.1002/cjp2.17
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2015
Sabine A, Bovay E, Demir CS, Kimura W, Jaquet M, Agalarov Y, Zangger N, Scallan JP, Graber W, Gulpinar E, Kwak BR, Mäkinen T, Martinez-Corral I, Ortega S, Delorenzi M, Kiefer F, Davis MJ, Djonov V, Miura N, Petrova TV. FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature. J Clin Invest. 2015 Oct 1;125(10):3861-77. doi: 10.1172/JCI80454
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2015
Salgado R*, Denkert C*, Demaria S*, Sirtaine N, Klauschen F, Pruneri G, Wienert S, Van den Eynden G, Baehner FL, Penault-Llorca F, Perez EA, Thompson EA, Symmans WF, Richardson AL, Brock J, Criscitiello C, Bailey H, Ignatiadis M, Floris G, Sparano J, Kos Z, Nielsen T, Rimm DL, Allison KH, Reis-Filho JS, Loibl S, Sotiriou C, Viale G, Badve S, Adams S*, Willard-Gallo K* and Loi S* (*contributed equally). The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an International TILs Working Group 2014. Ann Oncol. 2015 Feb;26(2):259-71. doi: 10.1093/annonc/mdu450
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2015
Schell MJ, Yang M, Missiaglia E, Delorenzi M, Soneson C, Yue B, Nebozhyn MV, Loboda A, Bloom G, Yeatman TJ. A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome. Clin Cancer Res. 2016 Feb 1;22(3):734-45. doi: 10.1158/1078-0432
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2015
Sinicrope FA, Shi Q, Smyrk TC, Thibodeau SN, Dienstmann R, Guinney J, Bot BM, Tejpar S, Delorenzi M, Goldberg RM, Mahoney M, Sargent DJ, Alberts SR. Molecular Markers Identify Subtypes of Stage III Colon Cancer Associated With Patient Outcomes. Gastroenterology. 2015 Jan;148(1):88-99. doi: PMID: 25305506
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2015
Tzouvadaki I, Puppo F, Doucey M-A, De Micheli G, Carrara S. Modeling Memristive Biosensors. Proceedings of the IEEE Sensors, Busan, South Korea.. doi: Conference Paper
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2015
Verdonck M, Garaud S, Duvillier H, Willard-Gallo K, Goormaghtigh E. Label-free phenotyping of peripheral blood lymphocytes by infrared imaging. Analyst. 2015 Apr 7;140(7):2247-56. doi: 10.1039/c4an01855a
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2015
Vuillefroy de Silly R, Ducimetière L, Yacoub Maroun C, Dietrich PY, Derouazi M, Walker P. Phenotypic switch of CD8(+) T cells reactivated under hypoxia toward IL-10 secreting, poorly proliferative effector cells. Eur J Immunol. 2015 Aug;45(8):2263-75. doi: 10.1002/eji.201445284
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2014
 
2014
Barras D, Lorusso G, Lhermitte B, Viertl D, Rüegg C, Widmann C. Fragment N2, a caspase-3-generated RasGAP fragment, inhibits breast cancer metastatic progression. Int J Cancer. 2014 Jul 1;135(1):242-7.. doi: 10.1002/ijc.28674
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2014
Belmont PJ, Budinska E, Jiang P, Sinnamon MJ, Coffee E, Roper J, Xie T, Rejto PA, Derkits S, Sansom OJ, Delorenzi M, Tejpar S, Hung KE, Martin ES. Cross-species analysis of genetically engineered mouse models of MAPK driven colorectal cancer identifies hallmarks of human disease. Dis Model Mech. 2014 Jun;7(6):613-23. doi: doi: 10.1242/dmm.013904. PMID 24742783
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2014
Bossard C, Dobay MP, Parrens M, Lamant L, Missiaglia E, Haioun C, Martin A, Fabiani B, Delarue R, Tournilhac O, Delorenzi M, Gaulard P, de Leval L. Immunohistochemistry as a valuable tool to assess CD30 expression in peripheral T-cell lymphomas: high correlation between protein and mRNA expression. Blood. 2014 Nov 6;124(19):2983-6.. doi: doi: 10.1182/blood-2014-07-584953. PMID: 25224410
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2014
C. Lohri, CS Schaltegger, M. Van Den Broek, R.H. Wenger, C. Ruegg, D. Fink, M.K. Fehr, A. Knuth, M. Zweifel. Neutrophil expression of ICAM1, CXCR1, and VEGFR1 in patients with breast cancer before and after adjuvant chemotherapy. Anticancer Res. 2014 34(9): 4693-9.. doi: PMID: 25202046
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2014
Cornaz-Buros S, Riggi N, DeVito C, Sarre A, Letovanec I, Provero P, Stamenkovic I. Targeting cancer stem-like cells as an approach to defeating cellular heterogeneity in Ewing sarcoma. Cancer Res. 2014 Nov 15;74(22):6610-22. doi: 10.1158/0008-5472.CAN-14-1106
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2014
D. Barras, G. Lorusso, C. Rüegg. Widmann Inhibition of cell migration and invasion mediated by the TAT-RasGAP317-326 peptide requires the DLC1 tumor suppressor. Oncogene. 2014;33(44):5163-72. doi: doi: 10.1002/ijc.28674
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2014
Di Narzo AF, Tejpar S, Rossi S, Yan P, Popovici V, Wirapati P, Budinska E, Xie T, Estrella H, Pavlicek A, Mao M, Martin E, Scott W, Bosman F, Roth A, Delorenzi M. Test of four Colon Cancer Risk-Scores in FFPE Microarray Gene Expression data. J Natl Cancer Inst. 2014: Sep 22: 106(10).. doi: doi: 10.1093/jnci/dju247. PMID: 25246611
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2014
Dietrich PY, Dutoit V, Walker PR. Immunotherapy for glioma: from illusion to realistic prospects?. Am Soc Clin Oncol Educ Book. 2014:51-9. doi: 10.14694/EdBook_AM.2014.34.51
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2014
Eveline Faes van’t Hull, Sylvian Bron, Luc Henry, Assia Ifticene-Treboux, Riccardo Turrini, George Coukos, Jean-François Delaloye, Marie-Agnès Doucey. Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer. Oncoimmunology. doi: e29080
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2014
Francesca Puppo · Marie-Agnes Doucey · Massimiliano Di Ventra · Giovanni De Micheli · Sandro Carrara. Memristor-based devices for sensing. IEEE International Symposium on Circuits and Systems (ISCAS) Melbourne, Australia. doi: Conference Paper
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2014
Garaud S, Gu-Trantien C, Lodewyckx JN, Boisson A, De Silva P, Buisseret L, Migliori E, Libin M, Naveaux C, Duvillier H, Willard-Gallo K. A simple and rapid protocol to non-enzymatically dissociate fresh human tissues for the analysis of infiltrating lymphocytes. J Vis Exp. 2014 Dec 6;(94). doi: 10.3791/52392
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2014
Jandus C, Boligan KF, Chijioke O, Liu H, Dahlhaus M, Démoulins T, Schneider C, Wehrli M, Hunger RE, Baerlocher GM, Simon HU, Romero P, Münz C, von Gunten S. Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J Clin Invest. 2014;124:1810-20. doi: 10.1172/JCI65899
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2014
Lohri C, Schaltegger CS, VAN DEN Broek M, Wenger RH, Ruegg C, Fink D, Fehr MK, Knuth A, Zweifel M.. Neutrophil expression of ICAM1, CXCR1, and VEGFR1 in patients with breast cancer before and after adjuvant chemotherapy.. Anticancer Res. 2014 Sep;34(9):4693-9..
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2014
Missiaglia E, Jacobs B, D'Ario G, F. Di Narzo AF, Soneson C, Eva Budinska E, Popovici V, Vecchione L, Gerster S, Pu Yan P, Roth AD, Dirk D, Bosman F, Delorenzi M, Tejpar S. Distal and proximal colon cancers differ in terms of molecular, pathological and clinical features. Ann Oncol. 2014 Oct;25(10):1995-2001. doi: doi: 10.1093/annonc/mdu275. PMID: 25057166.
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2014
Monaco A, Michelin O, Prior J, Rüegg C, Scapozza L, Seimbille Y. Synthesis of a non-peptidic PET tracer designed for α5β1 integrin receptor. J Labelled Comp Radiopharm. 2014 May 15;57(5):365-70. doi: 10.1002/jlcr.3190
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2014
N. Guex, I. Crespo, S. Bron, A. Ifticene-Treboux, E. Faes van’t Hul, S. Kharoubi, R. Liechti1, P. Werffeli, M. Ibberson, F. Majo, M. Nicolas, J. Laurent, A. Garg, K. Zaman, H-A. Lehr, B. J. Stevenson1, C. Rüegg, G. Coukos, J.-F. Delaloye, I. Xenarios and M.-A. Doucey. Angiogenic activity of breast cancer patients' monocytes reverted by combined use of systems modeling and experimental approaches. PLOS Computational Biology. doi: 10.1371
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2014
Nichita C, Ciarloni L, Monnier-Benoit S, Hosseinian S, Dorta G, Rüegg C. A novel gene expression signature in peripheral blood mononuclear cells for early detection of colorectal cancer. Aliment Pharmacol Ther. 2014;39(5):507-17.. doi: 10.1111/apt.12618
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2014
Ozdemir BC, Hensel J, Secondini C, Wetterwald A, Schwaninger R, Fleischmann A, Raffelsberger W, Poch O, Delorenzi M, Temanni R, Mills IG, van der Pluijm G, Thalmann GN, Cecchini MG. The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches. PLoS One. 2014 Dec 8;9(12):e114530.. doi: doi: 10.1371/journal.pone.0114530. PMID: 25485970.
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2014
Puppo F, Doucey M-A, Delaloye JF, Moh T, Pandraud G, Sarro PM, De Micheli G and Carrara S. High Sensitive Detection in Tumor Extracts with SiNW-FET in Air-Biosensors. Proceeedings of the IEEE Sensors, Valencia, Spain, Nov 3-5.
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2014
Puppo F, Doucey M-A, Di Ventra M, De Micheli G and Carrara S., Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS, 2014, Melbourne, Australia, June 1-5, 2014.. Memristor-Based Devices for Sensing. Proceedings of the IEEE International Symposium on Circuits and Systems, ISCAS, 2014, Melbourne, Australia.
» PubMed
2014
Puppo, Francesca; Doucey, Marie-Agnès; Di Ventra, Massimiliano; De Micheli, Giovanni; Carrara, Sandro. Memristor-Based Devices for Sensing. Memristor-Based Devices for Sensing (ISCAS), p. 2257-2260.
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2014
Ragusa S, Cheng J, Ivanov KI, Zangger N, Ceteci F, Bernier-Latmani J, Milatos S, Joseph JM, Tercier S, Bouzourene H, Bosman FT, Letovanec I, Marra G, Gonzalez M, Cammareri P, Sansom OJ, Delorenzi M, Petrova TV. PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnthigh Metastatic Colon Cancer Cells. Cell Rep. 2014 Sep 17. doi: doi: 10.1016/j.celrep.2014.08.041. PMID: 25242332
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2014
Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suvà ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Cancer Cell. 2014 Nov 10;26(5):668-81. doi: 10.1016/j.ccell.2014.10.004
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2014
Schou JV, Rossi S, Jensen BV, Nielsen DL, Pfeiffer P, Høgdall E, Yilmaz M, Tejpar S, Delorenzi M, Kruhøffer M, Johansen JS. miR-345 in Metastatic Colorectal Cancer: A Non-Invasive Biomarker for Clinical Outcome in Non-KRAS Mutant Patients Treated with 3rd Line Cetuximab and Irinotecan. PLoS One 2014, 9(6):e99886.. doi: doi: 10.1371/journal.pone.0099886. eCollection 2014. PMID: 24940606.
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2014
Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Ziccheddu G, Sestili P, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G, Zitvogel L. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. 2014 Nov;20(11):1301-9.. doi: doi: 10.1038/nm.3708. PMID: 25344738.
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2014
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de Leval L, Rickman DS, Thielen C, Reynies Ad, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, Berger F, Gisselbrecht C, Xerri L, Gaulard P. The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood. 2007 Jun 1;109(11):4952-63.
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2007
Desmedt C, Piette F, Loi S, Wang Y, Lallemand F, Haibe-Kains B, Viale G, Delorenzi M, Zhang Y, d'Assignies MS, Bergh J, Lidereau R, Ellis P, Harris AL, Klijn JG, Foekens JA, Cardoso F, Piccart MJ, Buyse M, Sotiriou C; TRANSBIG Consortium. Strong time dependence of the 76-gene prognostic signature for node-negative breast cancer patients in the TRANSBIG multicenter independent validation series. Clin Cancer Res. 2007 Jun 1;13(11):3207-14.
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2007
Gong Y, Yan K, Lin F, Anderson K, Sotiriou C, Andre F, Holmes FA, Valero V, Booser D, Pippen JE Jr, Vukelja S, Gomez H, Mejia J, Barajas LJ, Hess KR, Sneige N, Hortobagyi GN, Pusztai L, Symmans WF. Determination of oestrogen-receptor status and ERBB2 status of breast carcinoma: a gene-expression profiling study. Lancet Oncol. 2007 Mar;8(3):203-11.
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2007
Ignatiadis M, Perraki M, Apostolaki S, Politaki E, Xenidis N, Kafousi M, Stathopoulos E, Lianidou E, Sotiriou C, Georgoulias V, Mavroudis D. Molecular detection and prognostic value of circulating cytokeratin-19 messenger RNA-positive and HER2 messenger RNA-positive cells in the peripheral blood of women with early-stage breast cancer. Clin Breast Cancer. 2007 Dec;7(11):883-9. doi: 10.3816/CBC.2007.n.054
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2007
Ignatiadis M, Xenidis N, Perraki M, Apostolaki S, Politaki E, Kafousi M, Stathopoulos EN, Stathopoulou A, Lianidou E, Chlouverakis G, Sotiriou C, Georgoulias V, Mavroudis D. Different prognostic value of cytokeratin-19 mRNA positive circulating tumor cells according to estrogen receptor and HER2 status in early-stage breast cancer. J Clin Oncol. 2007 Nov 20;25(33):5194-202.
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2007
Lagneaux L, Gillet N, Stamatopoulos B, Delforge A, Dejeneffe M, Massy M, Meuleman N, Kentos A, Martiat P, Willems L, Bron D. Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response. Exp Hematol. 2007 Oct;35(10):1527-37.
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2007
Loi S, Haibe-Kains B, Desmedt C, Lallemand F, Tutt AM, Gillet C, Ellis P, Harris A, Bergh J, Foekens JA, Klijn JG, Larsimont D, Buyse M, Bontempi G, Delorenzi M, Piccart MJ, Sotiriou C. Definition of clinically distinct molecular subtypes in estrogen receptor-positive breast carcinomas through genomic grade. J Clin Oncol. 2007 Apr 1;25(10):1239-46.
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2007
Mariotti A, Perotti A, Sessa C, Rüegg C. N-cadherin as a therapeutic target in cancer. Expert Opin Investig Drugs. 2007 Apr;16(4):451-65.
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2007
Masson F, Calzascia T, Di Berardino-Besson W, de Tribolet N, Dietrich PY, Walker PR. Brain microenvironment promotes the final functional maturation of tumor-specific effector CD8+ T cells. J Immunol. 2007 Jul 15;179(2):845-53.
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2007
Merimi M, Klener P, Szynal M, Cleuter Y, Bagnis C, Kerkhofs P, Burny A, Martiat P, Van den Broeke A. Complete suppression of viral gene expression is associated with the onset and progression of lymphoid malignancy: observations in Bovine Leukemia Virus-infected sheep. Retrovirology. 2007 Jul 23;4:51.
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2007
Merimi M, Klener P, Szynal M, Cleuter Y, Kerkhofs P, Burny A, Martiat P, Van den Broeke A. Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code. J Virol. 2007 Jun;81(11):5929-39.
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2007
Sasaki K, Zhu X, Vasquez C, Nishimura F, Dusak JE, Huang J, Fujita M, Wesa A, Potter DM, Walker PR, Storkus WJ, Okada H. Preferential expression of very late antigen-4 on type 1 CTL cells plays a critical role in trafficking into central nervous system tumors. Cancer Res. 2007 Jul 1;67(13):6451-8.
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2007
Sotiriou C, Piccart MJ. Taking gene-expression profiling to the clinic: when will molecular signatures become relevant to patient care? Nat Rev Cancer. 2007 Jul;7(7):545-53.
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2007
Stamatopoulos B, Meuleman N, Haibe-Kains B, Duvillier H, Massy M, Martiat P, Bron D, Lagneaux L. Quantification of ZAP70 mRNA in B cells by real-time PCR is a powerful prognostic factor in chronic lymphocytic leukemia. Clin Chem. 2007 Oct;53(10):1757-66.
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2007
Zhu X, Nishimura F, Sasaki K, Fujita M, Dusak JE, Eguchi J, Fellows-Mayle W, Storkus WJ, Walker PR, Salazar AM, Okada H. Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
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before 2007
 
2006
Buyse M, Loi S, van't Veer L, Viale G, Delorenzi M, Glas AM, d'Assignies MS, Bergh J, Lidereau R, Ellis P, Harris A, Bogaerts J, Therasse P, Floore A, Amakrane M, Piette F, Rutgers E, Sotiriou C, Cardoso F, Piccart MJ; TRANSBIG Consortium. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J Natl Cancer Inst. 2006 Sep 6;98(17):1183-92.
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2006
Sotiriou C, Wirapati P, Loi S, Harris A, Fox S, Smeds J, Nordgren H, Farmer P, Praz V, Haibe-Kains B, Desmedt C, Larsimont D, Cardoso F, Peterse H, Nuyten D, Buyse M, Van de Vijver MJ, Bergh J, Piccart M, Delorenzi M. Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst. 2006 Feb 15;98(4):262-72.
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2005
Zaric J, Rüegg C. Integrin-mediated adhesion and soluble ligand binding stabilize COX-2 protein levels in endothelial cells by inducing expression and preventing degradation. J Biol Chem. 2005 Jan 14;280(2):1077-85.
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2004
Rüegg C, Dormond O, Mariotti A. Endothelial cell integrins and COX-2: mediators and therapeutic targets of tumor angiogenesis. Biochim Biophys Acta. 2004 Mar 4;1654(1):51-67.
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2003
Gagnoux-Palacios L, Dans M, van't Hof W, Mariotti A, Pepe A, Meneguzzi G, Resh MD, Giancotti FG. Compartmentalization of integrin alpha6beta4 signaling in lipid rafts. J Cell Biol. 2003 Sep 29;162(7):1189-96.
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2003
Rüegg C, Mariotti A. Vascular integrins: pleiotropic adhesion and signaling molecules in vascular homeostasis and angiogenesis. Cell Mol Life Sci. 2003 Jun;60(6):1135-57.
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2003
Sotiriou C, Neo SY, McShane LM, Korn EL, Long PM, Jazaeri A, Martiat P, Fox SB, Harris AL, Liu ET. Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10393-8.
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2002
Dormond O, Bezzi M, Mariotti A, Rüegg C. Prostaglandin E2 promotes integrin αVβ3-mediated endothelial cell adhesion, Rac activation, and spreading through a cAMP/PKA-dependent effect. J. Biol. Chem. 2002, 277:45838-45846.
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2001
Dans M, Gagnoux-Palacios L, Blaikie P, Klein S, Mariotti A, Giancotti FG. Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem. 2001 Jan 12;276(2):1494-502.
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2001
Dormond O, Foletti A, Paroz C, Rüegg C. NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat Med. 2001 Sep;7(9):1041-7.
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2001
Mariotti A, Kedeshian PA, Dans M, Curatola AM, Gagnoux-Palacios L, Giancotti FG. EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol. 2001 Oct 29;155(3):447-58. Epub 2001 Oct 29.
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1998
Rüegg C, Yilmaz A, Bieler G, Bamat J, Chaubert P, Lejeune FJ. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFNgamma. Nature Med. 1998, 4:408-414 (with news and views article).
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1998
Wary KK, Mariotti A, Zurzolo C, Giancotti FG. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell. 1998 Sep 4;94(5):625-34.
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1993
Palmer EL, Rüegg C, Ferrando R, Pytela R, Sheppard D. Sequence and tissue distribution of the integrin alpha9 subunit, a novel partner of beta1 that is widely expressed in epithelium and muscle. J. Cell Biol. 1993, 123:1289-1297.
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1992
Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ. Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J Cell Biol. 1992 Apr;117(1):179-89.
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1989
Rüegg C, Chiquet-Ehrismann R, Alkan SS. Tenascin, an extracellular matrix protein, exerts immunomodulatory activities. Proc. Natl. Acad. Sci. USA 1989, 86:7437-7441.
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